卫海荣教授
 
姓名: 卫海荣
职务: 密歇根理工大学助理教授
单位: 森林资源与环境科学学院
生物技术研究中心
计算机科学系(兼职)
霍顿,密歇根 49931
联系电话:(906)487-1473
    (906)487-2915
电子邮箱: hairong@mtu.edu
 
研究兴趣:生物信息,分子生物学和植物育种
· 通过基因网络的构建和分解辨别控制复杂性状的基因
· 控制木质素生物合成的分层基因网络
· 控制杨树根系的生长和发育分层基因网络
· 算法和软件开发
· 生物数据库设计和开发
· 植物遗传育种
 
学历和教育背景
1. 博士    植物分子生物学,夏威夷大学
2. 硕士    计算机科学,芝加哥大学
3. 硕士   林木遗传与育种,北京林业大学,
4. 学士    水土保持,北京林业大学
5. 博士后  生物信息学,美国明尼苏达大学
6. 博士后  生物统计学,阿拉巴马大学伯明翰分校
 
工作经历
2013~ 至今  兼职教授,东北林业大学,林木遗传育种国家重点实验室
2008~ 至今  助理教授,密歇根理工大学,霍顿密西根州
2006~2008   生物信息学开发研究员,Wicell 公司,麦迪逊,威斯康星州
2005~2006   生物信息学科学家,Operon生物技术公司,亨茨维尔,阿拉巴马
2004~2005   博士后,生物统计学,阿拉巴马州,伯明翰,阿拉巴马大学
2003~2004年   博士后研究,生物信息学,明尼苏达大学,明尼阿波利斯,明尼苏达
1996~2001年   助理研究员,植物分子。夏威夷大学生物学,夏威夷州檀香山
1995~1996年   助理研究员,植物遗传学,夏威夷,火奴鲁鲁,夏威夷大学
1989~1995年   助理教授及讲师,森林遗传学,北京林业大学
 
发表论文
1)Wei, H. Y. Yordan, S. Kumari, T. Georgieva, V. Busov. 2013. Genetic networks involved in poplar root response to low nitrogen. Plant Signal and Behavior. (https://www.landesbioscience.com/journals/psb/article/27211/)
2) Lin, Y.C.*, Li, W., Sun, Y.H., Kumari, S., Wei, H., Li, Q.Z., Tunlaya-Anukit, S., Sederoff, R.R., and Chiang, V.L. (2013). SND1 transcription factor-directed quantitative functional hierarchical genetic regulatory network in wood formation in Populus trichocarpa. Plant Cell25(11) 4324-4341.
3)Li, J. H. Wei, and P. Zhao. GPLEXUS: Enable genome-scale gene regulatory network analysis for plants through ultrafast mutual information computing and filtering. Nucleic Acids Research. Online now: http://nar.oxfordjournals.org/content/early/2013/10/30/nar.gkt983.full
4)Wei, H. Y. Yordan, T. Georgieva, X. Li, V. Busov. 2013. Nitrogen deprivation promotes Populus root growth via global transcriptomic reprogramming and activation of hierarchical genetic networks. New Phytologist 200 (2): 483-497.
5)Lu, S., Li, Q., Wei, H., Chang, M.J., Anukit, S.T., Kim, H., Liu, J., Song, J., Sun, Y.H., Yuan, L., Yeh, T.F., Peszlen, I., Ralph, J. Sederoff, R.R., Chiang, V.L. 2013. Ptr-miR397a is a negative regulator of laccase genes affecting lignin content in Populus trichocarpa. Proc Natl Acad Sci USA 110 (26) 10848-10853.
6) Li, J. H. Wei, T. Liu, X. Dai, P.X. Zhao. 2013. Legume: An integrative platform for comparative genomics and transcriptomics of model legumes. Book Chapter in Biological Nitrogen Fixation. (In press)
7)Li, J, H. Wei and P. X. Zhao. 2013. DeGNServer: Deciphering genome-scale gene networks through high performance reverse engineering analysis. Biomed Research International 2013 (2013), Article ID 856325
8)Liu, Z., Song, D. Yang, Wei, H. and Zhang, H. 2013. Effects of soil salinity on growth, ion relations and compatible solute accumulation of two sumac species: Rhus glabra and Rhus trilobata. Communications in Soil Science and Plant Analysis, 44(21):3187-3204
9)Wei, H. J. Gou, Y. Yordanov, H. Zhang, R. Thakur, W. Jones, A. Burton. 2013. Global transcriptome profiling of aspen trees under elevated [CO2] for identifying potential molecular mechanisms responsible for enhanced growth. Journal of Plant Research. V126, No 2: 305-320.
10)Kumari, S., J. Nie,, H.S. Chen, R. Stewart, H. Ma, X. Li, M. Lu, W.M. Taylor, and H. Wei. 2012. Evaluation of gene association methods for coexpression network construction and biological knowledge discovery. PLoS ONE 7(11): e50411. doi:10.1371/journal.pone.0050411. 0050411.
11)Ma. H. Houttler, C., H. Wei, M. Recroad III, J. Yao. 2012. Characterization of the rainbow trout oocyte microRNA transcriptome (Oncorhynchus mykiss). PLoS ONE 7(6): e39649. doi:10.1371/journal.pone.0039649.
12)Nie, J., R. Stewart, F. Ruan, J. Thomson, H. Zhang, X. Cui and H. Wei.2011.TF-Cluster: a pipeline for identifying functionally coordinated transcription factors via network decomposition of the shared coexpression connectivity matrix (SCCM). BMC Systems Biology, 5:53.
13)Cui, X, T. Wang, H.S. Chen, V. Busov and H. Wei. 2010. TF-Finder: A software package for identifying transcription factors involved in biological processes using microarray data and existing knowledge base. BMC Bioinformatics, 11:425.
14)Wei, H., P. F. Kuan, S. Tian, C. Yang, J. Nie, S. Sengupta, V. Ruotti, G. Jonsdottir, S. Keles, J. Thomson and R. Stewart. 2008. A study of the relationships between oligonucleotide properties and hybridization intensities in NimbleGen platform. Nucleic Acids Research, Vol. 36, No. 9:2926-2938.
15)Ming, R., S. Hou, Y. Feng, Q. Yu, A. Dionne-Laporte, J. Saw, P. Senin, W. Wang, S. Salzberg, X. Wang, E. Lyons, D. Rice, M. Riley, R. Skelton, J. Murray, C. Chen, M. Eustice, E. Tong, H. Albert, R. E. Paull, M.-L. Wang, Y. Zhu, M. Schatz, N. Nagarajan, R. Agbayani, P. Guan, A. Blas, J. Wang, J.-K. Na, T. Michael, E. V. Shakirov, B. Haas, J. Thimmapuram, D. Nelson, H. Tang, J. E. Bowers, J. Suzuki, S. Tripathi, K. Neupane, H. Wei, R. Singh, B. Irikura, N. Jiang, W. Zhang, K. Wall, G. Presting, A. Gschwend, Y. Li, A. Windsor, R. N. Pérez, M. J. Torres, F. A. Feltus, B. Porter, M. Paidi, M.-C. Luo, L. Liu, D. Christopher, P. H. Moore, T. Sugimura, C. dePamphilis, J. Jiang, M. Schuler, T. Mitchell-Olds, D. Shippen, J. Palmer, M. R. Freeling, A. H. Paterson, D. Gonsalves, L. Wang and M. Alam. 2008. The draft genome of the transgenic tropical fruit tree papaya, Carica papaya. Nature, Vol. 452, No. 7190:991-996.
16)Pan, P., S. Tian, J. Nie, C. Yang, V. Ruotti, H. Wei, G. Jonsdottir, R. Stewart, and J. Thomson. 2007. Whole genome analysis of Histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell, Vol. 1, No 3:299~312.
17)Wei, H, S. Persson, T. Mehta, V. Srinivasasainagendra, L. Chen, G. Page, C. Somerville, A. Loraine. 2006. Transcriptional coordination of the metabolic network in Arabidopsis thaliana. Plant Physiology. 142(2):762-74.
18)Persson, S., H. Wei, J. Milne, G. Page, C. Somerville. 2005. Identification of genes required for cellulose synthesis by regression analysis of public microarray data sets. Proc Natl Acad Sci USA, 102: 8633-8638. (This is a Faculty 1000 Prime's peer-recommended article)
19)Wei, H., Y. Kaznessis. 2005. Inferring gene regulatory relationships by combining target-target pattern recognition and regulator-specific motif examination. Biotechnology and Bioengineering. Vol. 89, No1: 53-77.
20)Wei, H. & Yiannis Kaznessis. 2004. Inferring gene regulatory networks using microarray data and SQL SERVER. Minnesota Supercomputing Institute Research Bulletin. Vol. 20, N0 2: 1-3.
21)Lee, K.M., S. Bhawan, T. Majima, H. Wei, V. Kumar. 2003. Cutting Edge: The NK cell receptor 2B4 augments Ag-specific CTL activity through CD48 ligation on neighboring T cells. Journal of Immunology. Vol.170, No 10: 4881.
22)Wei, H., H. Albert and P. Moore. 2003. Comparative expression analysis of two sugarcane polyubiquitin promoters and flanking sequences in transgenic plants. Journal of Plant Physiology 160, 1241-1251.
23)Wei, H., H. Albert and P. Moore. 1999. Differential expression of sugarcane polyubiquitin gene and isolation of promoters from two highly expressed members of the gene family. Journal of Plant Physiology, Vol. 155, p513-519.
24)Wei, H., F. Li., Y. Zhu, T. Dong. 1995. Some correlations between leaf structures of elms and resistance to leaf beetles. Journal of Beijing Forestry University (English edition). Vol.4, No. 1, pp.17-26.
25)Wei, H. 1994. Heterosis and cross breeding of forest trees (review). Journal of Heibei Forestry College. Vol.9, No.1, pp. 92-96.
26)Wei, H., and Y., Zhu. 1991. Breeding strategies of Ulmas pumila. Genetic Improvement on Broadleaf Trees. Huang, M and Tu, Z (eds). Scientific and Technical Document Publisher, pp. 263-270.
27)Wei, H. 1990. Comparison of genetics gain between two breeding strategies: clonal selection and seed orchard. Forestry Science and Technology. Vol. 236. No.1, pp 13-14.
28)Wei, H. 1989. Studies on juvenile-mature correlation between quantitative traits and early selection ages of Ulmus pumila. Journal of Inner Mongolia Forestry College. Vol.11.
 
开发的软件
5.8GAM: Eight gene association methods for constructing co-expression network
7.Top-down GGM and Bottom-up GGM algorithms. To be submitted in 2013.
 
获得的专利
1.Albert, H and H. Wei. Sugarcane Ubi9 gene promoter and methods of use thereof. 2004, U.S. Patent No. 6706948 (http://www.uspto.gov). (This patent was licensed by one of the biggest agricultural company).
2.Albert, H and H. Wei. Promoter of the sugarcane Ubi9 gene. 2004. U.S. Patent No. 6686513 B1 (http://www.uspto.gov).
3.Albert, H and H. Wei. Promoter of the sugarcane Ubi4 Gene. 2003. U.S. Patent No. 6638766 (http://www.uspto.gov).
 
课程和教学 (密西根理工大所教课程)
1.FW4099 生物信息技术及编程, 秋季 2009, 2011, 2013
2. FW5082 基因表达数据分析, 秋季 2010, 2012
3.CS2321 数据结构和JAVA, 春季 2011
4.FW5510 图象和 R 编程, 春季 2012
5.BMB6030 高级生物学实验, 春季 2013, 2014
6.FW3320 遗传基础, 春季 2013
7.FW3200 生物测量技术和数据分析春季 2014
 
研究生与访问学者
博士后: 1 人
博士研究生: 3人;
硕士研究生: 3人
访问教授/学者总人数:4人
 
兼职和服务
1.杂志编委
The Frontier of Plant Physiology 2011 ~ present
JSM Cell, 2013 - present
2.植物基因组大会顾问委员会
3.美国植物生理协会专业会员
4.国际计算生物学专业会员
5.密歇根理工大学任职
森林资源学院环境学院计算机委员会委员 (2012~ 现在)
森林资源与环境学院国际合作委员会委员(2011~ 现在)
生物化学与分子生物学(BMB)指导委员会(2012~ 现在)。
生物技术邀请委员会(2011-2013年)的会员。
战略招聘计划委员会(SFHI)(2009-2012年)
 
学术报告
1)Wei, H. Identification of genes controlling complex traits through network construction and decomposition. Faculty Forum Presentation, School of Forest Resources, Michigan Tech. (Oral presentation)
2)Wei, H. (Invited) Direct identification of genes controlling complex traits from gene expression data. Plant Genomics Congress. Sept 23-24, 2013. St. Louis, Missouri, USA. (Oral presentation)
3)Wei, H. (Invited) Constructing of hierarchical gene networks for identifying genes controlling root development and wood formation. Aug 26, 2013, Northeast Forestry University, Harbin, P.R. China. (Oral presentation)
4)Wei, H. Top-down and Bottom-up graphic Gaussian model algorithms for constructing hierarchical gene regulatory network. Aug 30, 2013. Chinese Academy of Forestry, Beijing, P.R. China. (Oral presentation)
5)Wei, H. (Invited) Systems biology approaches for identifying genes controlling complex traits and biological pathway: an exploration. Department of Biology Seminar, Michigan Tech. Mar 8, 2013. (Oral presentation)
6)Wei, H. The Global transcriptome profiling of aspen trees under elevated [CO2] for identifying potential molecular mechanisms responsible for enhanced growth. The 2013 Plant & Animal Genome XXII, San Diego, USA, 2013 (Poster)
7)Wei, H. (Invited). New strategies for forest tree breeding.Institute of Forestry and Pomology, Beijing Academy of Agriculture and Forestry Sciences. June 7, 2012. (Oral presentation)
8)Wei, H. (Invited) Identification of genes controlling a complex trait via systems biology approaches: an exploration. Workshop of System Biology held on Samuel Roberts Nobel Foundation, Apr 19 ~21, 2012. (Oral presentation)
9)Wei, H. Biotech research status and progress at Michigan Tech. Institute of Forest Biotechnology Partnership Conference. Nov 14, 2011, Raleigh, North Carolina, USA. (Oral presentation)
10)Wei, H. Two software pipelines for identifying key regulatory genes controlling a biological process. Chinese Academy of Forestry, July 19, 2011. P.R. China. (Oral presentation)
11)Wei, H. New algorithms and approach for construction of local subnetwork, Monsanto, Dec 2. 2011. St. Louis, Missouri, USA. (Oral presentation)
12)Wei, H. Systems biology approaches for identifying genes controlling a trait. Life College, Beijing University, Dec 29, 2011. P.R. China. (Oral presentation)
13)Wei, H. (Invited) Identifying genes regulating complex traits. School of Forestry, Northeast Forestry University, Dec 21, 2011, P.R. China. (Oral presentation)
14)Wei, H. New algorithms for identifying transcription factors regulating biological pathway. Syngenta Biotechnology, Raleigh, NC. Apr 1, 2011. (Oral presentation)
15)Wei, H. Identifying Key Transcription Factors Controlling Biological Processes of Interest. Institute of Botany, The Chinese Academy of Sciences. Aug 1, 2011 (Oral presentation)
16)Wei, H. Two methods for identifying transcription factors involved in biological processes. 19th Plant & Animal Genome Conference. January 15~19, 2011, San Diego, California, USA. (Oral presentation)
17)Wei, H. A pipeline for adequately recognizing transcription regulators involved a biological process using microarray data and existing knowledge base. American Association of Plant Biologists Annual Conference, 2010, Montreal, Canada. (Oral presentation)
18)Wei, H. (Invited). International Conference on Sustainable Management of Multi-purpose Poplar Plantations, IUFRO, China, 2010. (Oral presentation)
19)Wei, H. Integration of biological knowledge by integrating biological models. Department Biology Seminar Series, Michigan Tech, Oct 8, 2009. (Oral presentation)
20)Wei, H, V. Busov, and A. Storer. A comparative systems biology approach to elucidate resistance mechanisms of ash trees to EAB. Emerald Ash Borer Conference, Pittsburgh, Oct 20-21, 2009 (Oral presentation)
21)Wei, H, S. Persson , T. Mehta , V. Srinivasasainagendra , L. Chen , G. Page , C. Somerville, A. Loraine. Transcriptional coordination of the metabolic network in Arabidopsis thaliana. 17TH International Conference on Arabidopsis Research, Madison, Wisconsin, 2006 (Poster)
22)Wei, H., S. Persson, G. Page, A. Loraine, D. Allison, C. Somerville. A-large-scale analysis of hundred microarray data sets for identify genes involved in cell wall formation. The 2005 Plant & Animal Genome XIII, San Diego, USA, 2005. (Poster)
23)Barge, J., H. Wei, David Allison, Tomas Prolla, Richard Weindruch, 2004, Patterns of gene expression in multiple tissues of calorie-restricted mice. Molecular Genetics of Aging. October 6–10, 2004. Cold Spring Harbor, New York. (Poster)
24)Wu, X., D. Moellering, H. Vestri, H. Wei, L. Maianu, J. Rosinski, B. Rhees, V. So, D. Allison, M. Martin, T. Garvey. Dysregulation of Mitochondria-Related Genes in Skeletal Muscle from Insulin Resistant Humans Is Associated with Suppression of Transcription Factors Involved in Mitochondrial Biogenesis. American Diabetes Association Annual Conference, 2005. (Poster)
25)Wei, H., Y. Kaznessis. Make sense of microarray data. The 2003 Annual Conference of American
a. Institute of Chemical Engineers, Nov16-21, San Francisco, CA (Oral presentation)
26)Wei, H., H. Albert and P. Moore. Characterization of two sugarcane polyubiquitin gene promotersand matrix attachment regions for gene regulation in monocots. The 2001 Plant & Animal Genome IX, San Diego, USA, 2001. (Oral presentation)
27)Wei, H., H. Henrik and P. Moore. Isolation and characterization of two constitutive sugarcane gene promoters for genetic engineering of agriculturally important crops. Conference of Hawaii Sugarcane Technology, Maui, Hawaii, 1999. (Poster)
28)Wei, H., H. Albert and P. Moore. Isolation and characterization of two strong constitutivepromoters from sugarcane. 10th Ann. CTAHR Student Research Symposium, 1998. (Oral presentation).
29)Moore, P., H, Wei, H. Albert. Expression of two sugarcane polyubiquitin promoters in transgenic sugarcane, rice and tobacco. The International Conference of Animal and Plant Genome in San Diego, USA, 1999 (Oral presentation)
30)Wei, H., H. Albert. Differential expression of sugarcane polyubiquitin genes. 9th Ann. CTAHR Student Research Symposium. 1997. (Poster)